| ncRNA name | ERK5 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human microvascular endothelial cells (HMVECs), human retinal microvascular endothelial cells (HRMECs) |
| Methods | siRNA transfection, qRT-PCR, Western blot, ELISA |
| Expression pattern | associated |
| Functional description | Fibronectin (FN) production and deposition in the tissue is a characteristic feature of diabetic retinopathy. ERK5 is a recent member of the mitogen activated protein kinase (MAPK) family. siERK5 treatment led to an increase of FN synthesis. siERK5 transfection enhanced TGFβ1 mRNA expression. |
| PubMed ID | 23188731 |
| Year | 2012 |
| Title | ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes. |
| Drug-related ncRNA | NO |
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